Helen Keller has a history of prioritizing evidence-based approaches and cost-effective nutrition and health interventions. We have worked with the Government of Nepal (GoN) to integrate and mainstream nutrition in the national agenda, building national capacity through partnerships with academic institutions and international donors. Between 2012-2021 Helen Keller conducted a series of research projects in partnership with the University of Illinois, the University of Washington, Tufts University, Kansas State University, and Utah State University. We have conducted research on various topics, including maternal exposure to mycotoxins, post-harvest loss reduction, and improving the resilience of small mixed farm systems to climate change, among others. Additionally, we also conducted policy analyses and advocacy efforts related to the Breast Milk Substitute Act and the development of national standards for commercially produced complementary foods. Projects such as Multiple Micronutrient Supplementation (MMS), Innovative Metrics and Methods for Agriculture and Nutrition Actions (IMMANA) and Strengthening Economic Evaluation for Multisectoral Strategies for Nutrition (SEEMS) aim to improve economic, nutrition, and health outcomes.